Noveon AA1 as enhancer of HPMC as a direct compression matrix for controlled release.
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Date
2014-11
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Abstract
This work aimed the assessment of the effect of different proportions of Noveon AA1 on performance of HPMC
as a controlled release agent for direct compression tablets. The functionality of polymer blends was determined
using dissolution profiles, compactibility profiles and the powders compressibility index. Ten percent HPMC
allows a metronidazole release after 3 h of 85%, an exponent n=0.48 and a release constant K=6.9. The
increasing polymer substitution by Noveon AA1 decreases drug dissolution up to 36%, increases the exponent to
1.0 and decreases the release constant to 0.2%. The metronidazole/HPMC blend shows a slower increasing and a
lower potential of tablets compactibility (20 N) while its increasing substitution by Noveon AA1 attains faster
increasing and higher potential compactibilities (39 N). The metronidazole/HPMC (90:10) blend shows a low
compressibility index (14%) that increases up to 33.2% with increasing Noveon AA1 proportions. Noveon AA1
proportions ≤ 5% display good/passable powder flowabilities. Noveon AA1 enhances the overall controlled
release performance of HPMC, inducing zero order release patterns without lag or burst effects and reducing
drug release more efficiently. Noveon AA1 also improves the compactibility of metronidazole/HPMC blends,
however, decreases their flowability; flowability is acceptable only at lesser polymer proportions.
Description
Keywords
Tablet hardness, Compactibility, Powder flowability, compressibility index, Dissolution profile, Dissolution mechanisms, Metronidazole
Citation
Laguna-López Sara, Villafuerte-Robles Leopoldo. Noveon AA1 as enhancer of HPMC as a direct compression matrix for controlled release. Journal of Applied Pharmaceutical Science. 2014 Nov; 4(11): 62-68.