Assessment of cytotoxic activities of Phyllanthus amarus and Monstera deliciosa.
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Date
2014-07
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Abstract
Medicinal plants constitute an important component of flora and are widely distributed in Bangladesh. The
pharmacological evaluation of substances from plants is an established method for the identification of lead
compounds which shows the way to the development of novel and safe medicinal agents. Based on the
ethnopharmacological literature two widely used medicinal plants Phyllanthus amarus and Monstera deliciosa
were chosen to investigate their cytotoxicity through brine shrimp lethality bioassay which is simple, reliable and
convenient method for assessment of bioactivity of medicinal plants. The plants were collected from their natural
habitat, dried under shade and extracted with ethyl acetate. In this study, ethyl acetate extract of Phyllanthus
amarus exhibited potent cytotoxicity with LC50 values of 9.15μg/ml and 20.16μg/ml of leaves and the whole
plant respectively. Monstera deliciosa exhibited cytotoxicity with LC50 values of 36.60μg/ml and 300.4 μg/ml of
leaves and branches respectively. From the result, it can be predicted that extractives of Phyllanthus amarus
possess cytotoxic principles and showed significantly more potency than in leaves rather than whole plant. In
case of Monstera deliciosa the extractives of leaves exhibited very mild mortality while the extractives of
branches did not show considerable cytotoxicity.
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Keywords
Phyllanthus amarus, Monstera deliciosa, Brine shrimp, Cytotoxicity
Citation
Lira Dilshad Noor, Uddin Md Aftab, Uddin Mohi, Rouf Abu Shara Shamsur. Assessment of cytotoxic activities of Phyllanthus amarus and Monstera deliciosa. Journal of Applied Pharmaceutical Science. 2014 July; 4(7): 110-113.