Formulation and evaluation of fluconazole pro-niosomal gel for topical administration.
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Date
2014-07
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Abstract
The present investigation was aimed to explore the potential of proniosomal gel for the topical delivery of
fluconazole. Fluconazole-loaded proniosomes were prepared by the coacervation method using different nonionic
surfactants (spans and tweens) and evaluated for various parameters like size, shape, stability, entrapment
efficiency, in-vitro release, ex-vivo skin permeation and retention study. Results showed that proniosomes
composed of span 20 (F1), span 60 (F4), span 80 (F7) were more stable compared with tween 20 (F10) and tween
80 (F13) with smaller size, “i.e.” 4.08±0.18 μm, 2.61±0.15 μm, 2.01±0.12 μm, 8.56±0.20 μm, and 7.10±0.31 μm,
respectively, along with higher entrapment efficiency (approx. >46%). Ex-vivo skin penetration and retention
studies revealed that cutaneous deposition was affected by the nature of surfactant and vesicle size. Therefore the
proniosomes containing span 60 having high amount of drug retained in skin, “i.e.” 25.97±1.28 which can help
in localized delivery of drug especially in fungal mediated skin diseases, thereby increased efficacy for prolonged
period can be achieved.
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Keywords
Fluconazole, proniosome, surfactants, topical delivery, skin
Citation
Sandeep G, Vasavi Reddy D, Devireddy Srinivas Reddy. Formulation and evaluation of fluconazole pro-niosomal gel for topical administration. Journal of Applied Pharmaceutical Science. 2014 July; 4(7): 98-104.