Solid-pseudopapillary neoplasm of the pancreas: A clinicopathological and immunohistochemical study of 33 cases from a single institution in Southern India.
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Date
2015-04
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Abstract
Background: The clinicopathological and immunohistochemical data of
solid-pseudopapillary neoplasm (SPN) from India are limited. Our objectives
were to evaluate various histopathological parameters and immunomarkers
to elucidate the best possible immunomarker combination that can accurately
diagnose these tumors. Materials and Methods: Clinicopathological
features of 33 consecutive cases of SPN were retrospectively analyzed.
Immunohistochemistry (IHC) was performed on a tissue microarray of 31 of
these cases with antibodies to pan-cytokeratin (CK), vimentin, CD 10, E-cadherin,
β-catenin, estrogen receptor (ER), progesterone receptor (PR), chromogranin.
Results: Totally, 32 of 33 patients were females with a mean age of 26 years
(range 12-62 years). Majority presented with abdominal pain (93.93%) and/or
abdominal mass (48.48%). Location in pancreas included tail (14), head (7),
body and tail (6), body (5) and neck (1). The mean diameter of the tumor was
8.6 cm (range 0.5-16 cm). Surgical exploration was done in all cases. On IHC,
tumor cells were consistently positive for vimentin and negative for chromogranin
(100%). CK was positive in 12 cases (38.7%), CD 10 showed perinuclear
dot positivity in 14 (45.16%) cases and cytoplasmic positivity in 05 (16.12%)
cases. All cases showed loss of membranous staining for both β-catenin and
E-cadherin with nuclear positivity in 90.32% and 70.16% cases, respectively.
PR was positive in 20 (64.51%) cases, while all of them were negative for ER.
Conclusion: Solid-pseudopapillary neoplasm is a tumor commonly affecting
young females. Loss of membrane expression of β-catenin and E-cadherin with
nuclear positivity can be used confi rm the diagnosis of SPN.
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Keywords
Immunohistochemistry, pancreas, pathology, solid-pseudopapillary neoplasm
Citation
Uppin Shantveer G, Hui Monalisa, Thumma Venumadhav, Challa Sundaram, Uppin Megha S, Bheerappa Nagari, Sastry Regulagedda Adikesava, Paul Tara Roshni, Prayaga Aruna K. Solid-pseudopapillary neoplasm of the pancreas: A clinicopathological and immunohistochemical study of 33 cases from a single institution in Southern India. Indian Journal of Pathology & Microbiology. 2015 Apr-Jun 58(2): 163-169.