Choroidal metastases: Origin, features, and therapy.
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Date
2015-02
Authors
Arepalli, Sruthi
Kaliki, Swathi
Shields, Carol L
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The choroid is the most common ocular site for metastatic disease, owing to abundant vascular supply.
The primary cancers that most commonly lead to choroidal metastases include breast cancer (40-47%) and
lung cancer (21-29%). Bilateral, multifocal metastases are most often secondary to breast cancer, whereas
unilateral, unifocal metastasis are more commonly found with lung cancer. The treatment of choroidal
metastasis depends on the systemic status of the patient and number, location, and laterality of the
choroidal tumors. Treatment options include observation in patients with poor systemic status or those with
resolved or asymptomatic disease; systemic chemotherapy, immunotherapy, hormone therapy, or whole
eye radiotherapy if the metastases are active, multifocal and bilateral; plaque radiotherapy, transpupillary
radiotherapy, or photodynamic therapy for active, solitary metastasis; and enucleation for those with blind
painful eye. A database search was performed on PubMed, using the terms “choroidal metastasis,” or
“choroidal metastases,” in combination with terms such as “treatment,” “features,” or “diagnosis.” Relevant
articles were extracted and reviewed.
Description
Keywords
Choroid, Eye, metastases, metastasis, tumor, uvea
Citation
Arepalli Sruthi, Kaliki Swathi, Shields Carol L. Choroidal metastases: Origin, features, and therapy. Indian Journal of Ophthalmology. 2015 Feb; 63(2): 122-127.