Sclerotiorin is non-mutagenic and inhibits human PMNL 5-lipoxygenase and platelet aggregation.
Loading...
Date
2015-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
NISCAIR-CSIR, India
Abstract
Sclerotiorin, isolated from the fermented broth of Penicillium frequentans, exhibited potent inhibition against human polymorphonuclear leukocytes 5-lipoxygenase and human platelet aggregation with a half maximal value 36 µM and 250 µM, respectively. Further, the Ames test has demonstrated the sclerotiorin to be non-mutagenic.
Description
Keywords
Ames test, Fungal azaphilone, Penicillium frequentans
Citation
Chidananda C, Vasantha K Y, Sattur A P. Sclerotiorin is non-mutagenic and inhibits human PMNL 5-lipoxygenase and platelet aggregation. Indian Journal of Experimental Biology. 2015 Apr; 53(4): 228-231.