Endostar combined with chemotherapy compared with chemotherapy alone in the treatment of nonsmall lung carcinoma: A meta-analysis based on Chinese patients.
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Date
2014-03
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Abstract
INTRODUCTION: Lung cancer is the leading cause of cancer‑associated death world‑wide. And the lung cancer is generally divided into small
cell lung carcinoma and non-small cell lung cancer. For advanced NSCLC, the chemotherapy and target therapy were the important treatment
modality. This meta‑analysis was to evaluate the clinical efficacy and toxicity between endostar combined chemotherapy and chemotherapy alone
in Chinese patients. MATERIALS AND METHODS: We searched the PubMed, EMBASE, and CNKI databases to find the potential relevant articles
reporting the endostar combined with chemotherapy regimen in the treatment of nonsmall cell lung cancer in Chinese patients. The tumor response
and toxicity difference between the two groups were demonstrated by odds ratio (OR) and its 95% confidence interval (95% CI). All the data
was pooled by Stata 11.0 (https://www.stata.com; Stata Corporation, College Station, TX) software. RESULTS: We included 14 studies published
in Chinese or English studies. The pooled results showed adding endostar in the chemotherapy regimen can significant increase the objective
response rate (OR = 2.42, 95% CI = 1.87–3.12, P = 0.00) and disease control rate (OR = 2.22, 95% CI = 1.68–2.94, P = 0.00). For toxicities,
the pooled data showed no statistical difference for grade III‑IV granulocytopenia risk (OR = 1.04, 95% CI = 0.74–1.44, P = 0.83). Nausea and
vomiting (OR = 0.93 95% CI: 0.51–1.52, P = 0.78) and grade III‑IV alopecia (OR = 0.99, 95% CI: 0.76–1.29, P = 0.95). The funnel plot showed no
statistical publications. CONCLUSION: Combined treatment with endostar can improve the response rate for NSCLC patients without increasing
the risk of developing severe adverse event.
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Keywords
Chemotherapy, endostar, meta‑analysis, nonsmall cell lung cancer, response, toxicity
Citation
Wang J, Gu L J, Fu C X, Cao Z, Chen Q Y. Endostar combined with chemotherapy compared with chemotherapy alone in the treatment of nonsmall lung carcinoma: A meta-analysis based on Chinese patients. Indian Journal of Cancer. 2014 Mar; 51(7_Suppl): s106-s109.