Comparative effects of propofol and nitroglycerine on efficacy of rewarming in patients undergoing on-pump coronary artery bypass grafting.
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Date
2015-04
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Abstract
Objectives: To compare the effects of propofol and nitroglycerine (NTG) on the efficacy of rewarming, extra
volume added during cardiopulmonary bypass and extravascular lung water (EVLW) in patients undergoing
on‑pump coronary artery bypass grafting. Materials and Methods: A prospective, randomized, blinded
trial, twenty adult patients were randomly assigned to receive either NTG infusion (NTG group) or propofol
infusion (propofol group) during rewarming. Results: After drop in temperature at the end of surgery and till
24 h were significantly less in propofol group compare to NTG group (P < 0.025). Extra volume added during
cardiopulmonary bypass and net crystalloid balance till 24 h was less in the propofol group (P < 0.003).
There was no difference in EVLW and postoperative outcome. Conclusions: Propofol use during moderate
hypothermic cardiopulmonary bypass is associated with less after drop in temperature and less requirement
of extra fluid during the perioperative period.
Description
Keywords
Extravascular lung water, Fluid balance
Citation
Kumar Bhupesh, Chauhan Prerana, Thinganam K S Shyam. Comparative effects of propofol and nitroglycerine on efficacy of rewarming in patients undergoing on-pump coronary artery bypass grafting. Annals of Cardiac Anaesthesia. 2015 Apr; 18(2): 145-152.