Association of insulin resistance with redox imbalance in patients with non diabetic hypertension.
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Date
2010-08
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Abstract
Oxidative stress involved in the pathogenesis of several diseases.
Hypertension itself acts as source of oxidative stress. Insulin resistance is involved in the
pathogenesis of essential hypertension. In the present study an attempt was made to study the
association between insulin resistance and oxidative stress in non diabetic hypertensive
patients. Two hundred and three, non diabetic hypertensive patients and two hundred and ten,
healthy normotensive subjects were enrolled in this study. Malondialdehyde, reduced
glutathione, glutathione peroxidase, Fasting insulin and HOMA-IR levels were estimated in
both groups. Fasting insulin, reduced glutathione, glutathione peroxidase and MDA shows
significant difference between cases and controls. Among the patients HOMA-IR were
significantly correlated with lipid peroxides and shows negative correlation between HOMAIR
and glutathione peroxidase. Increased HOMA-IR was found in non diabetic hypertensive
patients. This study reveals the link between oxidative stress and insulin resistance.
Description
Keywords
Oxidative stress (redox imbalance), HOMA-IR, Essential hypertenstion, Malondialdehyde
Citation
Ramalingam K, Santha K, Sethupathy S, Kumar R Vinoth, Manigandan K. Association of insulin resistance with redox imbalance in patients with non diabetic hypertension. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Aug-Oct; 1(2): 703-708.