Anti-nociceptive and antimicrobial evaluation of mannich bases of 1H-Indoles.
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Date
2010-08
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Abstract
A series of several novel mannich bases of indoles (1A-L) have been
synthesized from indole by reacting with respective aldehyde and the various
compounds containing secondary amine. The synthesized compounds were
characterized by IR and 1HNMR spectral analysis. All the synthesized compounds
were evaluated for their anti-nociceptive activity in mice by Eddy’s hot plate
method. The reaction time was compared with standard drug pentazocine. In vitro
antimicrobial activity of the synthesized compounds were screened against the
Gram positive microorganisms such as Staphylococcus aureus, Streptococcus
pyogenes, Gram negative microorganisms such as Escherchia coli, Klebsiella
aerogenes and fungus Candida albicans by cup plate method. The zone of
inhibition of the synthesized compounds was compared with the standard drug
amikacin and ketoconazole respectively. All the synthesized compounds exhibited
significant anti-nociceptive activity and showed moderate antimicrobial activity.
Description
Keywords
Mannich base, Indole, anti-nociceptive, antibacterial, antifungal
Citation
Anandarajagopal K, Sunilson J Anbu Jeba, Kulkarini S D, Rajamanickam V, Jegan N, Promwichit P. Anti-nociceptive and antimicrobial evaluation of mannich bases of 1H-Indoles. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Aug-Oct; 1(2): 502-509.