Antidepressant activity of aqueous extract of fruits of emblica officinalis in mice.
Loading...
Date
2010-08
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Depression is a widespread psychiatric disorder affecting around 5% of the
population. Furthermore, it is difficult to predict which patient will respond to any given
treatment. In the traditional systems of medicine, many plants and formulations have been used
to treat depression for thousands of years. Emblica officinalis (EO) contains tannic acid as its
main ingredient and this compound has been shown to have non-selective mono-amine oxidase
activity. Therefore, the present study was undertaken to evaluate the antidepressant potential of
acute and chronic administration of EO in forced swim test (FST) and tail suspension test (TST).
Inbred adult male Swiss Albino mice weighing 25-30g were used in the study. Standard drug
(imipramine) and test drug (EO) were suspended in 1% gum acacia. The vehicle (10ml/kg, p.o),
imipramine (10mg/kg, p.o) and EO (0.8mg/kg, 2mg/kg, 4mg/kg, p.o. respectively) were
administered 1hour prior to acute study. In chronic study, all drugs were given for 10 days and
the last dose was given 1hour before the experiment. Duration of immobility was noted in both
the models. In our study, both imipramine and EO significantly reduced the duration of
immobility in both experimental models as compared to the animals in the control group. The
antidepressant activity of EO was comparable to that of standard drug imipramine. The results of
the present study indicate the potential for use of EO as an adjuvant in the treatment of
depression.
Description
Keywords
Forced swim test, Tail suspension test, Emblica officinalis, Depression
Citation
Pemminati Sudhakar, Gopalakrishna H N, Shenoy Ashok K, Sahu Sudhanshu Sekhar, Mishra Shishir, Meti Vinayak, Nair Vinod. Antidepressant activity of aqueous extract of fruits of emblica officinalis in mice. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Aug-Oct; 1(2): 448-454.