Design and evaluation of levofloxacin hemihydrate floating tablets.
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Date
2010-08
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Abstract
In the present study, the tablets were prepared by melt granulation method,
using the polymer, hydroxy propyl methyl cellulose (HPMC K100M) with different amounts
and other excipients and sodium bicarbonate as gas generating agent. The present study is to
develop a floatable drug delivery system of Levofloxacin hemihydrate for sustained drug
delivery and gastric retentive property with special emphasis on optimization of formulations
for floating matrix tablets. Thus the study aims to improve the oral bioavailability of the drug
and to achieve extended retention in the stomach which may result in prolonged absorption.
Tablets were evaluated by different parameters such as weight uniformity, content uniformity,
thickness, hardness, IR spectral analysis, in vitro release studies, Buoyancy determination and
kinetic analysis of dissolution data, stability studies Levofloxacin floating tablet drug delivery
system showed improved in-vitro bioavailability and extended drug release which may favour
the reduced dose frequency and patient compliance.
Description
Keywords
Levofloxacin Hemihydrate, Floating tablets, in vitro release study, Buoyancy determination
Citation
Arunachalam A, Rathinaraj B Stephen, Ch Rajveer, Kumaraswamy D, Umarunnisha A M. Design and evaluation of levofloxacin hemihydrate floating tablets. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Aug-Oct; 1(2): 260-268.