Chronological Primacy of Oxidative-Induced Neuronal Damage in the Pathogenesis of Alzheimer's Disease.
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Date
2013-04
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Abstract
Alzheimer’s disease (AD) is associated with hallmark pathologies including extracellular
Aβ protein deposition in extracellular senile plaques and vessels, and intraneuronal tau
deposition as neurofibrillary tangles.
The current study comprises the oxidative modifications associated with the pathological
lesions of neuronal damage characterized AD. The repeated exposure to aluminum and
heavy metals, mutations in a number of chromosomes and genes, diabetes,
cardiovascular diseases, obesity and brain injury, are the major causes for these
modifications.
There is clearly a need for the identification and development of panels of biomarkers for
accurate diagnosis and early detection of sporadic AD. Thus, a collection of the most
globally manifested expeditious diagnostic tools for early detection of AD is outlined in this
review. Also, a survey of the vast clinically approved therapeutic modalities for restricting
and even treating the symptoms of AD is summarized. These arguments provide useful
information in both understanding pathogenesis as well as accessing the novel treatment
approaches for AD.
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Keywords
Alzheimer’s disease (AD), pathogenesis, diagnosis and prognosis, therapeutic modalities
Citation
Estefan Selim F, Shalby Aziza B, Ahmed Hanaa H. Chronological Primacy of Oxidative-Induced Neuronal Damage in the Pathogenesis of Alzheimer's Disease. International Journal of Biochemistry Research & Review 2013 Apr-Jun ; 3 (2) : 82-96.