Protective action of curcumin and vitamin e against the imbalance of electrolytes calcium, sodium and potassium in galactose-induced cataract.
Loading...
Date
2010-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Cataract is a clouding that develops in the crystalline lens of the eye leading to
opacity. In this study we investigated the efficiency of curcumin and Vitamin E to regulate the
altered levels of Ca+2, Na+ and K+ ions in cataract induced rat lens. Also specific activity of
aldose reductase and the total and soluble lenticular protein levels in the lens were compared in
treated as well as control groups of rats. The data was analyzed using one-way ANOVA,
followed by post hoc test multiple comparisons and Karl Pearson’s correlation. Feeding of rats
with Curcumin and Vitamin E had resulted in a significant decrease (p<0.05) in Na+ and Ca2+
concentrations and an increase (p<0.05) in K+ concentration which is otherwise found to be
raised in cataractous condition. Also, a decrease in the specific activity of Aldose Reductase was
found along with the conservation of total and soluble lenticular protein levels in lens treated
with Curcumin and Vitamin E compared to cataract induced lens.
Description
Keywords
CURCUMIN, Vitamin E, Electrolytes, Galactose
Citation
Kumar C Sanat, Kumar V Vijay, Raju T Naga. Protective action of curcumin and vitamin e against the imbalance of electrolytes calcium, sodium and potassium in galactose-induced cataract. International Journal of Applied Biology and Pharmaceutical Technology. 2010 May-Jul; 1(1): 183-189.