Inhibition of angiotensin converting enzyme activity by reduced glutathione: A dose dependent invitro study.
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Date
2010-05
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Abstract
The Angiotensin converting enzyme (ACE) is a dipeptidyl
carboxypeptidase and plays an important role in the regulation of blood pressure. Several
potent inhibitors of this enzyme have been reported to be active antihypertensive agents.
Sulfhydryl (SH) group containing ACE inhibitors used as a antihypertensive agents.
Reduced glutathione (GSH) as antioxidant play an important role in reducing the blood
pressure. Several recent studies have shown that reduced glutathione enhance nitric oxide
pathway and increases the bioavailability of nitric oxide resulting in vasodilatation. In this
study reduced glutathione and oxidized glutathione (GS-SG) were investigated for inhibition
against ACE using Hip-His-Leu (HHL) as substrate. The inhibition of ACE by different
concentrations of reduced glutathione was much more than that of oxidized glutathione. The
inhibition of ACE by reduced glutathione ranges from 12.5% to 60%. Oxidized glutathione
shows less than 5% of inhibition. This study shows that apart from the antioxidant role,
reduced glutathione inhibits ACE activity which plays a crucial role in the regulation of
blood pressure.
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Keywords
Angiotensin converting enzyme (ACE), Reduced glutathione (GSH)
Citation
Ramalingam K, Sethupathy S, Santha K. Inhibition of angiotensin converting enzyme activity by reduced glutathione: A dose dependent invitro study. International Journal of Applied Biology and Pharmaceutical Technology. 2010 May-Jul; 1(1): 87-94.