Efficacy of Ferric Carboxymaltose in Anaemia of Malignancy - A Pilot Study.
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Date
2014-06
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Abstract
Anaemia is an important problem in
malignancy. It may be due to chronic causes like
malnutrition, marrow infiltration, associated renal or
endocrine disorders and it may be complicated with blood
loss. Measures like blood transfusion, erythropoietin
injections often pose a logistical problem. Parenteral iron
injections have proved to be useful in fighting anaemia in
some chronic conditions e.g. patients on hemodialysis. Aims
and Objectives: Primarily to see the observable change in
hemoglobin (Hb) level with ferric carboxymaltose (FCM)
in treating patients of malignancy on anti-cancer treatment.
Materials and Methods: Twenty seven patients were enrolled
for this study who were suffering from various malignancies.
The baseline Hb level was estimated and FCM injection
was administered as per the schedule of 500 mg
intravenously (IV) weekly once. The overall results of
increase in Hb level was noted during the middle of the
treatment (chemotherapy or radiotherapy) and later 3-4
weeks after treatment completion. The results were analysed
using SPSS and the mean values of initial Hb and after
treatment were analysed. Level of significance (p value)
was noted using t test. Results: In 27 patients the mean
initial Hb level was 8.09 g/dl before treatment which
increased to 10.28 g/dl after FCM treatment (p <0.0001).
Conclusion: Treatment with FCM definitely led to a
significant increase in Hb level in patients of malignancy
undergoing treatment. However, further detailed study is
needed to establish its definite role in improving the body
iron parameters.
Description
Keywords
anaemia, malignancy, ferric carboxymaltose
Citation
Dutta Samrat, Pandey Prashant, Modal Palash Kumar, Pal Partho Pratim. Efficacy of Ferric Carboxymaltose in Anaemia of Malignancy - A Pilot Study. Indian Medical Gazette. 2014 Jun ; 148 (6): 209-214.