Oxidant and Antioxidant Status in Parkinson’s Disease.
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Date
2014-06
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Abstract
Parkinson’s disease (PD) is a progressive, neurological
disease that mainly affects movements and occurs at older
ages and is clinically characterized by resting tremor, rigidity,
bradykinesia and postural imbalance. These clinical
manifestations of PD are caused by a selective degeneration
of dopamine-producing neurons in substantia nigra in the
brain stem and the consequent dopamine shortage in the
striatum. Oxidants and antioxidants related substances may
contribute to the pathogenesis and the progression of
Parkinson’s disease. Research can make great progress in
understanding and further treating the PD. This study
demonstrates significant variation of oxidants-antioxidants
status in Parkinson’s disease. Oxidative stress plays a crucial
role in progression of PD; however, oxidative stress is a
cause or the consequence of PD is debatable. In our study
we observed there is significant increase in the levels of
serum Malondialdehyde (p< 0.001), Nitric oxide end
products (p< 0.001), and significant decrease in the activity
of Glutathione peroxidase (p< 0.001), Superoxide dismutase
(p< 0.001), and Catalase (p< 0.001) in PD patients as
compared with controls. Further Vitamin C (p< 0.05),
Vitamin E (p< 0.05) significantly decreased, but Uric acid
levels (p> 0.05) remain unchanged and this may be due to
compensatory mechanism of body against oxidative stress,
which not allowed much alteration in other parameter in
the PD patients as compared with controls.
Description
Keywords
malondialdehyde, nitric oxide, glutathione peroxidase, superoxide dismutase, catalase, uric acid, parkinson’s disease
Citation
Mahindrakar Yashpal Shankarrao, Iyer C M, Thorat Anand P. Oxidant and Antioxidant Status in Parkinson’s Disease. Indian Medical Gazette. 2014 Jun ; 148 (6): 195-202.