Amoxycillin Clavulanic Acid Induced Hepatotoxicity.
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Date
2014-05
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Abstract
Drug-related hepatotoxicity is a serious health problem,
with broad implications for patients, healthcare providers,
the pharmaceutical industry and governmental regulatory
agencies. Herein we report a rare case of amoxycillinclavulanic
acid combination induced liver injury of
cholestatic pattern in 40 years old, well educated male
patient. Patient gave history that though other drugs were
given to him by his physician for fever with chills & rigors,
malaise, bodyache, except amoxycillin-clavulanic acid
combination all other drugs were well tolerated previously
by the patient, without appearance of jaundice. So jaundice
in this patient was most probably due to amoxycillinclavulanic
acid combination. Though severe liver injury is
rare, proper history should be taken while prescribing
amoxycillin-clavulanic acid combination. Attention must
be paid to potential side-effects of the drugs and close
follow-up with patients is a medical necessity to evaluate
adverse reactions, especially in case of amoxycillinclavulanic
acid combination.
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Keywords
amoxycillin-clavulanic acid combination, DILI, hepatotoxicity
Citation
Gursale Santosh C, Burte Narayan P. Amoxycillin Clavulanic Acid Induced Hepatotoxicity. Indian Medical Gazette. 2014 May ; 148 (5): 192-194.