Laryngopharyngeal Reflux and Proton Pump Inhibitors.
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Date
2014-05
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Abstract
Laryngopharyngeal reflux (LPR) refers
to the backflow of stomach contents into the throat that is
into the hypopharynx.LPR is different from classical
GERD. Although PPIs appear to be effective, higher doses
for a longer duration are necessary as compared with
esophageal GERD disease. In this study we focused on
clinical characteristics and role of proton pump inhibitors
in Laryngopharyngeal Reflux. Material and Methods: The
prospective observational study was done in LPR patients
in the Department of ENT and HNS of SKIMS Medical
College and Government Medical College Srinagar for a
period of 2 years from 2010 to 2012 .Sixty cases were
enrolled in the study. LPR was diagnosed on the basis of
RFS and RSI. Role of PPI was assessed by the changes of
RSI and RFS with Proton pump inhibitors. Results: Total
number of patients included in the study were 60, 42 (70%)
cases were females, 18 (30%) were males. Frequent clearing
of throat was the most common symptom. Mean RSI of
all patients was 25.25 before treatment. Significant change
in RSI occurred after first 10 weeks of therapy and no
further significant change occurred in the next 10 weeks.
Most common laryngeal finding was erythema/hyperaemia;
Mean RFS of the patients was 13 before treatment with
proton pump inhibitors. There was slight response after
10 weeks of therapy in physical findings and significant
response after 20 weeks. Conclusion: LPR is a common
condition presenting in ENT settings, the symptoms and
signs may be complex. PPI are treatment of choice and
should be continued for about 5 months because clinical
symptoms take about two month to resolve while signs
take about 5 months to resolve.
Description
Keywords
laryngopharyngeal reflux, GERD, proton pump inhibitors, RFS
Citation
Khan Nazir A, Ahmed Shakil, Nazia, Suhail, Islam Mudasir ul. Laryngopharyngeal Reflux and Proton Pump Inhibitors. Indian Medical Gazette. 2014 May ; 148 (5): 167-175.