Significance of AgNOR in Salivary Gland Tumours.
Loading...
Date
2014-03
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Diagnosis of Salivary gland
tumours is challenging, because of wide variation in
differentiation and overlapping morphological features.
Sometimes, the difficulty encountered in distinguishing
between pleomorphic adenoma, adenoid cystic carcinoma
and adenocarcinoma. The objective is to study the application
of AgNOR pattern in differentiating benign and malignant
tumours of the salivary glands on Fine needle aspirates and
their correlation with histopathology. Material and method:
Cytological material was obtained by FNAC from forty three
patients of salivary gland tumours. MGG and Pap stained
smears were prepared for cytological interpretation.
Histopathological study was done on routine formalin fixed
and Haematoxylin & Eosin stained sections. Smears and
sections were stained with Silver colloid stain for study of
AgNOR counting. Results: AgNOR in benign tumours were
small, round, uniform and less in number (1.02-1.97) while
in malignant tumours they were very large, irregular,
haphazardly distributed with high counts (1.23-16).
Conclusion: Present study shows that count as well as
morphology of AgNOR dots was helpful in differentiating
between benign and malignant tumours and their grading
of malignancy .
Description
Keywords
salivary gland, AgNOR, benign and malignant tumours
Citation
Singhal Mini, Acharya Seema, Kumar Rajnish, Kudesia Sandip. Significance of AgNOR in Salivary Gland Tumours. Indian Medical Gazette. 2014 Mar ; 148 (3): 84-86.