Comparison of the Minimum Fungicidal Concentration of Clotrimazole, Ketoconazole, Miconazole and Terbinafine Against Clinical Isolates of Dermatophytes.
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Date
2014-02
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Abstract
Superficial fungal infections affect millions of people
worldwide. Earlier most dermatophyte strains had relatively
restricted geographical distribution. But currently,
dermatophytosis has become one of the most common
human infectious diseases worldwide. Fungal infections
are common in hot and humid climate of tropical countries
like India.
Topical and systemic therapies are commonly used to
treat dermatophyte infections.Clotrimazole is one of the
most commonly used topical antifungal drugs. This study
compared the minimum fungicidal concentration (MFC)
of Clotrimazole with Miconazole, Ketoconazole and
Terbinafine in skin dermatophytes.
The study demonstrated that Clotrimazole had lower
MFCs as compared to Ketoconazole and Miconazole against
Trichophyton rubrum, Trichophyton mentagrophytes and
Microsporum canis. Clotrimazole had comparable MFCs
versus Terbinafine against Trichophyton rubrum but it had
lower MFCs against Trichophyton mentagrophytes and
Microsporum canis.
Thus, Clotrimazole is an effective antifungal agent for
dermatophytosis even today.The efficacy of Clotrimazole
even against strains with intermediate resistance or
resistance to the older azole anti fungal drugs reiterate the
current decisions of empirical treatment with topical
Clotrimazole for the management of superficial
dermatophyte infections.
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Keywords
dermatophytosis, clotrimazole, minimum fungicidal concentration (MFC)
Citation
Patankar M, Ahluwalia A, Bhargava A. Comparison of the Minimum Fungicidal Concentration of Clotrimazole, Ketoconazole, Miconazole and Terbinafine Against Clinical Isolates of Dermatophytes. Indian Medical Gazette. 2014 Feb ; 148 (2): 65-68.