Efficacy of Zinc Supplementation as an Adjunct to Anti Tubercular Drug Therapy.
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Date
2014-01
Journal Title
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Abstract
Zinc being a stronger electron acceptor than iron might
replace iron from the critical thiol groups. So, Zinc
supplementation in Tubercular Subjects might help the
decompartmentalised state of iron in the body to revert
back to normal compartmentalized state of iron. Again,
Zinc inhibits the formation of superoxide radicals. Thus,
Zinc supplementation might decrease the excess
superoxide with simultaneous decrease in the formation
of soluble oxygen made by dismutation reaction by the
iron cofactored superoxide dismutase secreted
extracellularly by the pathogenic M. tuberculosis. The study
shows early and effective recovery with Zinc
supplementation (50mgm. of elemental zinc orally / day
for one month) along with anti - Tubercular drug therapy.
This gets support by the significant changes in the serum
level of three enzymes – Glutamine Synthetase, Superoxide
Dismutase and Cholienesterase. Again, the dose of zinc
supplementation instituted with a great benefit and without
any toxic symptoms and signs, is below the Lowest
Observed Adverse Effect Level (LOAEL) based on the
superoxide dismutase activity in erythrocytes with zinc
intake.
Description
Keywords
Zinc (Zn) Supplementation, Glutamine Synthetase (GS), Superoxide Dismutase (SOD), Cholinesterase (ChE), Lowest Observed Adverse Effect Level (LOAEL)
Citation
Chattopadhyay Dipak Kumar, Nag Debabrata. Efficacy of Zinc Supplementation as an Adjunct to Anti Tubercular Drug Therapy. Indian Medical Gazette. 2014 Jan ; 148 (1): 21-24.