Level of Auto Antibody Against Oxidized LDL in Myocardial Infracted Patients.
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Date
2013-11
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Abstract
The aim of this study was to evaluate the
level of auto antibody against oxidized LDL in myocardial
infracted (MI) patients and normal healthy subjects of West
Bengal (India) and to establish it to be also a cofactor for
MI. Patients and Methodology : This study was carried
out on 285 patients with MI as well as 75 healthy volunteers
of comparable age and gender as control group. Blood was
collected immediately after admission of the patients. Auto
antibody against oxidized LDL, Nitric Oxide and
malondialdehyde (MDA) were measured in all groups.
Results : Mean serum level of auto antibody against oxidized
LDL, MDA, total Cholesterol and LDL Cholesterol levels
(118 ± 9.0, 7.4 ± 1.3, 233 ± 30, and 145 ± 38) were
significantly (p<0.05) higher in MI patients when compared
with control subject. The mean serum levels of nitric oxide
(NO) and HDL, cholesterol were significantly (p<0.05)
lower as compared to control group. Conclusion :
Significantly high level of auto antibody against oxidized
LDL associated with high level of MDA, total cholesterol
and decreased level of NO and HDL cholesterol appear to
be the factors responsible for the increase risk of coronary
artery disease i.e., myocardial infarction in the population
of West Bengal, India.
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Keywords
auto antibody against oxidized LDL, myocardial infarction, coronary artery disease, malondialdehyde
Citation
Ghoshal Pradip Kumar,Tanti Soumen, Biswas Asish, Mondal Raghab Chandra, Saha Jayanta, Meyur Rudradev. Level of Auto Antibody Against Oxidized LDL in Myocardial Infracted Patients. Indian Medical Gazette. 2013 Nov ; 147 (11): 410-416.