Langerhans Cell Histiocytosis Presenting with Hypopigmented Macules.
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Date
2013-07
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Abstract
Langerhans cell histiocytosis (LCH) is a complex disease
characterized by proliferation of the Langerhans cells. The
clinical course is variable and ranges from a solitary lytic
bone lesion or skin lesion with complete remission to a
multisystem disorder with possible lethal outcome. The
diagnosis is suspected by clinical signs and symptoms and
radiological features commonly in craniofacial bones and
skin lesions. Diagnosis is confirmed by biopsy and
immunohistochemical studies.
We present case of a 8 year old child presenting with
proptosis, diabetes insipidus and hypopigmented macules
on chest and back showing bilateral distribution which is a
rare presentation. Skin biopsy revealed the diagnosis of
Langerhans cell histiocytosis.
Description
Keywords
langerhans cell histiocytosis, hypopigmented macules, proptosis
Citation
Shere Sunita K, Patil Sunita P, Kulkarni Anjali S, Bindu Rajan S, Phulgirkar Pragati P. Langerhans Cell Histiocytosis Presenting with Hypopigmented Macules. Indian Medical Gazette. 2013 Jul ; 147 (7): 282-284.