Effects of Emblica Officinalis (AMLA) on Serum Lipids and Atherogenesis in Albino Rats Fed with High Fat Diet.
Loading...
Date
2013-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: To evaluate the effects of Emblica officinalis
(Amla) extract on serum lipids and atherogenesis, in albino
rats fed with high fat diet. Materials and Methods: Healthy
albino rats of Wistar strain (150-200 gm each) were
randomized into five groups of six animals each- Group A
(received normal diet), Group B (received normal diet +
Emblica officinalis extract 1 gm/kg BW) Group C (received
high fat diet consisting of vanaspati ghee and coconut oil at
a ratio of 3:2, at a dose of 10 ml/kg/day), Group D (received
high fat diet + Emblica officinalis extract 1 gm/kg BW)
and Group E (received high fat diet + simvastatin 1.8 mg/
kg BW). Treatment period was 8 weeks. At the end of 8
weeks, lipid profile was evaluated by estimating total
cholesterol, serum triglyceride, serum LDL, serum HDL
and atherogenic index. Results: Ethanolic extract of Emblica
officinalis showed significant antihyperlipidaemic activity
(P< 0.01) with significant improvement in atherogenic index
(p<0.01). Conclusion: Present study suggests that Emblica
officinalis extract at a dose of 1 gm/kg BW exerts
antihyperlipidaemic effect comparable to that of simvastatin.
It also possesses hypolipidaemic activity.
Description
Keywords
emblica officinalis, phyllanthus emblica, amla, indian gooseberry, high fat diet, atherogenesis, simvastatin, antihyperlipidaemic, hypolipidaemic
Citation
Lama Anju, Saikia Hiteswar. Effects of Emblica Officinalis (AMLA) on Serum Lipids and Atherogenesis in Albino Rats Fed with High Fat Diet. Indian Medical Gazette. 2013 Jul ; 147 (7): 271-275.