Liver Function Tests in Type 2 Diabetes Mellitus Patients with and without Oral Hypoglycemic Agents and Statin Intake.
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Date
2012-10
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Abstract
Background: Type 2 diabetes (T2DM) is often
associated with liver function abnormalities, covering the
entire spectrum from asymptomatic transamnitis to
cirrhosis. The oral drugs used in diabetes are also associated
with hepatic insult. Aims: Here we have tried to assess the
prevalence the liver function test abnormality in type 2
diabetes mellitus patients with special reference to intake
of oral hypoglycemic agents (OHA) and statins. Methods:
We selected 101 patients of Type 2 Diabetes mellitus
(T2DM). Among those diabetic patients 50 were on oral
hypoglycemic drugs (OHA) and statins for at least last 6
months. Another 51 age and sex matched patients were
diabetic but not on these drugs. The patients were screened
for any existing liver disease by biochemical tests. Results
and analysis: Our results showed that the prevalence of
elevated liver enzymes and bilirubin is more in Diabetic
patient than normal values but the oral hypoglycemic drugs
and statins had no added effect. Altogether 70 patients
(69.3%) had at least one liver function test abnormality. In
our study, 4.95% of the patients had elevated bilirubin (>2.5
mg/dL). 24.75% of the study patients had ALT levels above
normal (40 U/L) although high values (>100 U/L) were
present only in 5 (4.95%). High AST levels (>40) was found
in 34.65% cases. Mean alkaline phosphatase levels in 2
groups were similar (213.96 ± 46.2 vs. 222.75 ± 42.52 U/
L). Serum proteins, INR and alkaline phosphatase did not
also show any association with drug intake in our study.
Conclusion: Thus screening for liver function abnormalities
can be a useful test in diabetic population to prevent future
complications.
Description
Keywords
hepatotoxicity, transaminase, insulin resistance, blood glucose, glitazones, statin
Citation
Patra Tushar Kanti, Mondal Jayati, Paul Rudrajit, Baneijee Amit K, Mandal Sanjay Kumar, Bhattacharya Raja, Mandal Lopamudra. Liver Function Tests in Type 2 Diabetes Mellitus Patients with and without Oral Hypoglycemic Agents and Statin Intake. Indian Medical Gazette. 2012 Oct ; 145 (10): 388-393.