Comparative Analysis of the Distribution of Various Subtypes of Lymphoid Malignancies in Uttarakhand with other Regions in India.
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Date
2012-04
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Abstract
Lymphoid malignancies (LM) form an umbrella term
comprising both Hodgkin Disease (HD) and Non Hodgkin
Lymphoma (NHL). A number of studies conducted in India
and worldwide suggests that the disease exhibits similar
pattern with contrasting regional variations. Examining
regional variations is important as it may provide an insight
to the etiological factor and pathogenesis of the disease.
Aim: The aim of our study was to investigate the current
pattern of lymphoid malignancies both HD and NHL in
Uttarakhand and subsequently compare the results with other
regions. Materials and Methods: We analyzed 116 cases
of Lymphoid Malignancies that were reviewed over a period
of 18 months. Both HD and NHL were diagnosed
morphologically and then Immunohistochemistry (IHC)
using CD3, CD15, CD20, CD30, and CD45 was employed
to further subtype disease according to current WHO
classification. Results: The lymphoid malignancies were
further subdivided into HD and NHL. Nodular Sclerosis
(NS) was the dominant subtype of HD in Uttarakhand
(48.78%) and was comparable with results from other
regions. Statistical analysis regarding distribution of various
subtypes of HD in Uttarakhand and its comparison with
three distinct geographical regions also showed p value <
0.241832 which was not statistically significant. However,
amongst NHL Diffuse Large B cell Lymphoma (DLBCL)
(54.66%) was the commonest subtype. Besides, a
significant number of cases of Anaplastic Large Cell
Lymphoma (12%) were also observed. Furthermore,
statistical analysis showed that the distribution of various
subtypes of NHL in Uttarakhand when compared to three
distinct geographical regions was statistically significant
(P value < 0.002808). Conclusion: Geographic differences
in the incidence and histologic subtypes of Lymphomas do
exist.
Description
Keywords
Immunohistochemistry (IHC), Lymphoid, malignancies, Regional, Uttarakhand
Citation
Bhardwaj Aparna, Kusum Anuradha, Kishore Sanjeev. Comparative Analysis of the Distribution of Various Subtypes of Lymphoid Malignancies in Uttarakhand with other Regions in India. Indian Medical Gazette. 2012 Apr ; 145 (4): 147-152.