Osteopontin: A Novel Protein Molecule.
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Date
2012-02
Journal Title
Journal ISSN
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Abstract
Osteopontin (OPN) is phosphorylated sialic acid –rich
non-collagenous bone matrix protein. OPN is found in
several biological fluids including human plasma, serum,
breast milk and urine.OPN was named for its function as a
bridge between cells and minerals. OPN has been implicated
as an important factor in bone remodeling. Osteopontin is
expressed in immune cells, including macrophages,
neutrophils, dendritic cells with varying kinetics. OPN
influences cell mediated immunity and has Th 1 cytokine
functions .OPN is overexpressed in cancers of lung, breast,
colorectal, stomach and ovary.OPN is found in
atheromatous plaques within arteries. OPN plays an
important role during both acute and chronic inflammation.
OPN is upregulated in tissues during several pathological
process including atherosclerosis, valve stenosis,
myocardial infarction and rheumatic arthritis. OPN is a key
cytokine regulating tissue repair. OPN’s plasma levels are
elevated in overweight and obesity.
Description
Keywords
osteopontin (opn), inflammation, cancer, biomineralisation, vascular calcification, obesity, atherosclerosis
Citation
Sase Sudhir P, Nagane Nitin, Ganu Jayashree V. Osteopontin: A Novel Protein Molecule. Indian Medical Gazette. 2012 Feb ; 145 (2): 62-66.