Effect of Zinc Salts on Acid Secretion and Peptic Ulceration in Albino Rats.
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Date
2012-01
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Abstract
The present study was carried out to see the effect of
two zinc salts i.e zinc sulphate and zinc chloride on gastric
ulcers induced by stress, pylorus ligation and aspirin in
albino rats. The rats were divided into two main groups
(zinc sulphate 30, 60, 90 mg/kg i.p and zinc chloride 10
and 20mg/kg i.p). They were further sub-divided into three
sub-groups dependant on ulcer model i.e stress, pylorus
ligation and aspirin induced ulcers. It was found that zinc
sulphate and zinc chloride had a dose dependant reduction
in ulcer index in all three models of gastric ulceration. Also,
both the salts had anti acid secretory effect, raised pH of
gastric secretion and reduced total acidity significantly. Thus
zinc salts prevent gastric ulceration. Probably this effect is
mediated by anti acid secretory action.
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Keywords
stress, aspirin, pyloric ligation, anti-ulcer activity
Citation
Pimpalkhute Sonali A, Bajait Chaitali S, Kale Anand S, Nagdeote Abhay N. Effect of Zinc Salts on Acid Secretion and Peptic Ulceration in Albino Rats. Indian Medical Gazette. 2012 Jan ; 145 (1): 19-22.