Neonatal Septicemia due to Acinetobacter species and their Antimicrobial Susceptibility Pattern.
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Date
2011-10
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Abstract
Background and Objectives: Sepsis remains a clinical
challenge in the Indian intensive care nurseries. Neonatal
sepsis due to Acinetobacter species has been reported in
recent years. Because of their multidrug resistance pattern,
Acinetobacters pose a challenge regarding management of
patients. The present study was therefore undertaken to
find out the prevalence of Acinetobacter species in cases
of neonatal septicemia and also to find out the antimicrobial
susceptibility pattern of all Acinetobacter isolates.
Methods: Eighty Acinetobacter isolates from blood
culture samples from neonates with signs and symptoms
of septicemia were speciated by standard biochemical tests
and their antimicrobial susceptibility testing was done by
Kirby Bauer Disk Diffusion (KBDD) method according to
CLSI guidelines.
Results: Incidence of neonatal septicemia due to
Acinetobacter species was 9.18% out of total blood culture
positive samples and predominant species was
Acinetobacter baumanii (67.5%), followed by
Acinetobacter junii (20%). Acinetobacter species showed
maximum susceptibility to netilmicin (86.25%), followed
by imipenem (70%). Acinetobacter junii showed greater
susceptibility than Acinetobacter baumanii.
Conclusion: This study indicates that neonatal sepsis
due to Acinetobacter species is on the rise. Acinetobacter
baumanii is multiresistant type and has direct bearing on
mortality, so it highlights the importance of formulating a
proper antibiotic policy in every hospital in cases of neonatal
sepsis. The differences in resistant patterns among isolates
emphasizes the need for differentiating A. baumanii from
other Acinetobacter species by special biochemical tests.
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Keywords
acinetobacter, neonatal septicemia, antimicrobial susceptibility
Citation
Rathi M R, Mathur M M, De A S. Neonatal Septicemia due to Acinetobacter species and their Antimicrobial Susceptibility Pattern. Indian Medical Gazette. 2011 Oct ; 145 (10): 391-393.