Mössbauer Spectroscopic Analysis of Iron Containing Allopathic, Homeopathic and Ayurvedic Pharmaceutical Compounds.
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Date
2014-07
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Abstract
Mössbauer spectroscopy is an analytical tool to investigate the oxidation state and distortion
in chemical bonds around iron moiety of iron containing pharmaceutical compounds
(allopathic, homeopathy and ayurvedic). In the present work, Mössbauer spectroscopic
studies of different parameters like; isomer shift, quadrupole splitting and line width in
different unexpired and expired pharmaceutical compounds have been recorded. Changes in
the value of these parameters have been observed according to nature of compound. Line
width and quadrupole splitting values of the outdated allopathic samples containing ferrous
ascorbate (C18H21FeO18), ferrous fumarate (C4H2FeO4) and ferric hydroxide Fe(OH)3
increased significantly as compared to respective fresh samples. This is attributed due to the
weakening and distortion of bonds around iron moiety prior to change in the valence state.
Ayurvedic and homeopathic iron supplements exhibited remarkable consistency of
Mössbauer parameters even after long period of storage owing to the presence of
stoichiometrically pure and chemically stable ferric oxide (α-Fe2O3) in loh bhasam and
ferrous phosphate Fe3(PO4)2 in biochemic tablets.
Description
Keywords
Mössbauer study, Isomer shift, Quadrupole splitting, Line width
Citation
Kaur Manpreet, Sharma Saroj, Sharma Jitender Paul. Mössbauer Spectroscopic Analysis of Iron Containing Allopathic, Homeopathic and Ayurvedic Pharmaceutical Compounds. Indian Journal of Pharmaceutical & Biological Research. 2014 Jul-Sept ; 2 (3): 96-104.