Comparison between the conventional method & molecular line probe assay for identification & drug sensitivity of mycobacteria tuberculosis from clinical specimens.
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Date
2014-07
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Abstract
Rapid susceptibility testing of Mycobacterium tuberculosis strains is imperative for therapy
selection but traditional drug susceptibility tests take weeks or are expensive. Classical drug
susceptibility (DST) may take up to 2 to 4 months. The line probe assay is a commercially
available line-probe assay that rapidly detects Mycobacterium tuberculosis (MTB) complex,
as well as the most common mutations associated with rifampicin and isoniazid. In this study
we assessed the sensitivity and specificity of the rapid molecular method in comparison with
the conventional method.
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Keywords
Drug susceptibility – Mycobacterium, tuberculosis Line probe assay, tuberculosis
Citation
Kansal Ritu, Madan Molly, Kansal Richa, Agwan Vivek, Bansal Isha, Agrawal Nivesh. Comparison between the conventional method & molecular line probe assay for identification & drug sensitivity of mycobacteria tuberculosis from clinical specimens. Indian Journal of Pharmaceutical & Biological Research. 2014 Jul-Sept ; 2 (3): 80-83.