Physical Activity Related Risk Factor Assessment for Altered Drug Pharmacokinetics in Human Population.
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Date
2014-07
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Abstract
The study examined the intensity of an individual’s physical activity by using self
administered International Physical Activity Questionnaire Short Form 7 (IPAQ-SF7) as a
measuring tool and assessed its impact on the various body physiological functions likely to
alter drug pharmacokinetic processes. The study was conducted in normal, subjects inhabited
at different regions in India, with the translated versions of IPAQ-SF7 in Hindi and Tamil
languages found the high intensities of vigorous, moderate activities and walking and showed
excellent reproducibility as similar as it has been studied in different population worldwide.
The resting state systolic and diastolic blood pressures, heart rate and respiratory rate were
significantly higher in the subjects. The diaphragmatic breathing pattern was found used by
majority of the subjects. The energy utilization of the subjects on their physical activity was
obtained in high Metabolic Equivalence of Task (METs) minutes per week. Thus significance
in the physiological parameters was strong enough to alter the pharmacokinetics of drugs
whose metabolism and elimination are primarily dependent on renal function. This results
which will be helpful in optimizing and selecting the drug doses for the people under extreme
physical activity with less oxygen consumption in muscles, low level of respiratory rates and
high energy utilization in their body.
Description
Keywords
Physical Activity, International Physical activity, Questionnaire-Short Form 7, Reproducibility, Pharmacokinetics, Metabolic Equivalence of Task, (METs) minutes per week
Citation
Thomas Abhilash, Samanta Malay Kumar, Dubey Satendra K, Arun K P. Physical Activity Related Risk Factor Assessment for Altered Drug Pharmacokinetics in Human Population. Indian Journal of Pharmaceutical & Biological Research. 2014 Jul-Sept ; 2 (3): 43-53.