Hepatic stellate cells targeting – a specific approach to liver cirrhosis.
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Date
2014-07
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Abstract
Cirrhosis is one of the chronic generalised disease and has a variety of clinical manifestations
and complications some of which can be a life threatening. This results in decrease in
hepatocellular mass and thus functions. It is 12th leading cause of death in United States.
Hepatic stellate cells (HSC) plays a crucial role in the development of liver fibrosis because
of their prominent role in extracellular matrix production, regulation of vascular tone, and
production of inflammatory mediators such as transforming growth factor-b (TGF-b) and
platelet-derived growth factor (PDGF).Therefore, these cells are major target for the treatment
of Cirrhosis. Cell-specific delivery can provide a solution to these problems, but a specific
drug carrier for HSC has not been described until now. The mannose 6-phosphate/insulin-like
growth factor II (M6P/IGF-II) receptor, which is expressed in particular upon HSC during
fibrosis, may serve as a target-receptor for a potential carrier. Carrier molecules are designed
for their selective cellular uptake, taking advantage of specific receptors or binding sites
present on the surface membrane of the target cell.
Description
Keywords
Liver, Cirrhosis, Hepatic stellate cells targeting
Citation
Sahani Vandana, Bhatt Ganesh, Kothiyal Preeti. Hepatic stellate cells targeting – a specific approach to liver cirrhosis. Indian Journal of Pharmaceutical & Biological Research. 2014 Jul-Sept ; 2 (3): 3-11.