A review on recent innovation in osmotically controlled drug delivery system.
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Date
2014-04
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Abstract
In recent years, oral controlled release (CR) system is most acceptable dosage form by the
patients. Drugs having short biological half-life and poor water solubility are the suitable
candidate for development of CR system. They include dosage forms for oral and transdermal
administration as well as injectable and implantable systems. For most of drugs, oral route
remains as the most acceptable route of administration. Certain molecules may have low oral
bioavailability because of solubility or permeability limitations. Development of an extended
release dosage form also requires reasonable absorption throughout the gastro-intestinal tract
(GIT). Among the available techniques to improve the bioavailability of these drugs
fabrication of osmotic drug delivery system is the most appropriate one. The release of
drug(s) from osmotic systems follows zero order. It is mainly governed by various
formulation factors such as solubility and osmotic pressure of the core component(s), size of
the delivery orifice, and nature of the rate-controlling membrane. The present review
highlights an overview of OCDDS. And new technologies, fabrication and recent clinical
research in osmotic drug delivery. Further, the challenges of these technologies and its future
perspective are also discussed at length.
Description
Keywords
Osmotic pumps, Osmosis, Zero-order, Semipermeable membrane, Osmotic agent
Citation
Gupta Neetu R, Mishal Aditee, Bhosle Yogesh, Shetty Supriya. A review on recent innovation in osmotically controlled drug delivery system. Indian Journal of Pharmaceutical & Biological Research. 2014 Apr-Jun ; 2 (2): 117-129.