Fabrication and Optimization of Novel Lornoxicam Matrix Tablets Using 3-Factor 3-Level Box-Behnken Statistical Design: Invitro and Invivo Evaluation.
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Date
2014-04
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Abstract
In the present study efforts have been made to prepare sustained release matrix tablets of
Lornoxicam. Matrix tablets were prepared by direct compression method by using
Hydroxypropyl methyl cellulose K15 (HPMC- K15), Ethyl cellulose (EC) and Sodium
carboxy methyl cellulose (Na-CMC) as polymers in different concentrations. A 3-factor 3-
level Box-Behnken statistical design was used as an optimization tool having total of 17
experimental runs with 5 central points. All three polymers were selected as independent
variables while %age drug release at various time intervals and hardness were used as
dependant variables. In vivo studies were conducted on human plasma using Tenoxicam as
internal standered. All the detections were made on SYKNM HPLC. Foriour Transform
Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetery (DSC) studies were
conducted and no chemical interaction was found between drug and polymers. The drug
release mechanism was mainly governed by non-fickian (anomalous) diffusion and zero-order
(case II) transport diffusion. Regression analysis was performed on dissolution data obtained
with the selected response variables and polynomial models were constructed. Polynomial
models were further validated using one way ANOVA and results indicated that all the
polymers used have significant effect on selected response (p>0.05). Contour plots and three
dimensional response surface curves were drawn. In- vivo studies were conducted on two
tablet formulation indicating slow and sustained release of the drug from matrix. From
Behnken design it is possible to successfully formulate and optimize Lornoxicam sustained
release matrix tablets with three polymers (HPMC- K15, EC and Na-CMC) in combination.
Description
Keywords
Matrix tablets, Lornoxicam, Box Behnken statistical design Polymers, Direct compression method
Citation
Iqbal A, Sarfraz R M, Mahmood A, Ahsan H, Zaman M, Bashir I, AkramM A. Fabrication and Optimization of Novel Lornoxicam Matrix Tablets Using 3-Factor 3-Level Box-Behnken Statistical Design: Invitro and Invivo Evaluation. Indian Journal of Pharmaceutical & Biological Research. 2014 Apr-Jun ; 2 (2): 87-95.