Timed Release of Valsartan from Programmable Release Capsules: Importance of Plasticizers.
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Date
2013-10
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Abstract
The objective of the present study was to evaluate the effect of different plasticizers on the
ethylcellulose coatings of capsules and its timed release characteristics. Various plasticizers
such as dibutyl phthalate (DBP), triacetin (TA), glycerol, triethyl citrate (TEC), polyethylene
glycol-4000 and polyethylene glycol-6000 (PEG) were studied. The physicochemical
properties of the casted polymeric films such as mechanical resistance, water uptake and dry
weight loss were determined. Also the type and concentration of plasticizer on timed release
of the capsule was studied. The drug release was found to be strongly dependent on the type
of plasticizer and was in the order of GY>TA>PEG 6000>PEG 4000>TEC>DBP. Capsules
coated with hydrophobic DBP (5%) showed good release with a lag time of 6 ± 0.5 h. DBP
provided mechanically resistant coatings on the capsule and remained within the polymeric
films without leaching upon exposure to the release media which helped in maintaining the
lag time.
Description
Keywords
Plasticizers, Timed release, Polymeric films, Tensile strength, Dibutyl phthalate
Citation
Nayak Usha Yogendra, Shavi Gopal Venktesh. Timed Release of Valsartan from Programmable Release Capsules: Importance of Plasticizers. Indian Journal of Pharmaceutical & Biological Research. 2013 Oct-Dec ; 1 (4): 102-107.