Antidiabetic Effect of Pleurotus ostreatus (Jacq.ex Fr) kumm.Mushroom on Alloxan-induced Diabetic Rats.
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Date
2013-04
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Abstract
Antidiabetic effects of ethanolic extract of Pleurotus ostreatus (mushroom) on alloxan-induced diabetic rats
was studied. The median lethal dose (LD50) of the extract was determined to be 3,472.14 mgkg-1 and a single
dose of 380.0, 760.0 and 1140.0 body weight of the extract were intraperitoneally administered as the
treatment dose and the blood glucose levels (BGL) examined for 7 hours and 15 hours (prolonged) at 2 and 4
hours intervals respectively. The extract exhibited significant (p<0.05 and p<0.01) reduction in the blood
glucose levels of the albino rats. The extract compared favourably with the standard reference drug
(metformin) which all gave their maximum BGL reduction at 5 hours duration. The confirmation of
antidiabetic potentials of the Pleurotus ostreatus tuber has been justified in this study as claimed by
traditional medicine practitionersin Akwa Ibom State.
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Keywords
Pleurotus ostreatus, diabetic rats, hypoglycaemic activity, ethanolic extract, metformin
Citation
Johnny Imoh, Okon Joseph. Antidiabetic Effect of Pleurotus ostreatus (Jacq.ex Fr) kumm.Mushroom on Alloxan-induced Diabetic Rats. Indian Journal of Pharmaceutical & Biological Research. 2013 Apr-Jun; 1 (2): 31-36.