Pediatric Vasculitides: A Generalists Approach.
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Date
2010-10
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Abstract
Vasculitis is defined as the presence of inflammation
in a blood vessel that may occur as a primary
process or secondary to an underlying disease. Primary
vasculitides are rare in children. These are defined by both
the size of vessels involved and the type of inflammatory
response. Clinical features consist of multi-organ involvement
on a background of constitutional features reflecting
the size and location of the blood vessels involved. Whilst
some vasculitides are best diagnosed clinically, many forms
require sophisticated imaging and other investigations (auto
antibodies) to reveal the correct diagnosis. Prompt recognition
and treatment is crucial as many of the vasculitides
cause significant morbidity or mortality. Treatment options
range from symptomatic therapy, immunosuppresive agents,
intravenous immunoglobulin (IVIG) or biologic agents and
are determined by the type of vasculitis, the severity of the
inflammation, and the organ systems affected. Early detection
and aggressive treatment is crucial for the best outcomes in the
most severe forms of childhood vasculitis.
Description
Keywords
Vasculitis, Classification, Approach, Management, ANCA
Citation
Khubchandani Raju P, Viswanathan V. Pediatric Vasculitides: A Generalists Approach. Indian Journal of Pediatrics. 2010 Oct; 77 (10): 1165-1171.