YnfA , a SMR family efflux pump is abundant in Escherichia coli isolates from urinary infection.
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Date
2015-01
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Abstract
A quantitative study was undertaken to determine the expression level of different effl ux pumps in
multi-drug-resistant (MDR) Escherichia coli isolates from urinary infection. We have determined the presence of
different effl ux pumps and measured the expression level of tolC, mdfA, norE and ynfA genes among 48 isolates by
quantitative real-time PCR. The expression level of tolC and ynfA was constantly high and observed among 75-80% of
isolates, whereas mdfA and norE were expressed occasionally. Our fi ndings suggest that ynfA, a new SMR effl ux pump
gene family member increases the antibiotics’ resistance in E. coli.
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Keywords
Antibiotic resistance, effl ux pumps, small multi-drug resistance family, ynfA
Citation
Sarkar S K, Bhattacharyya A, Mandal S M. YnfA , a SMR family efflux pump is abundant in Escherichia coli isolates from urinary infection. Indian Journal of Medical Microbiology. 2015 Jan-Mar ; 33 (1): 139-142.