A preliminary study of recombinant human interferon-α-2a activity against rabies virus in murine model.
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Date
2015-01
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Abstract
Rabies remains an important public health problem in the world due to uncontrolled enzootic rabies. Although rabies
associated fatalities may be prevented with timely immunoprophylaxis, but till date a therapeutic molecule has
remained elusive. We investigated the role of rhuIFN α-2a in murine model challenged with rabies virus. Titre of 104.25
LD50/0.03 ml of 10% w/v RV CVS stock suspension were obtained. Based on 1LD50 titre, challenge dose of 50 LD50
was administered along with rhuIFN α-2a with pre-exposure (primed) and post-exposure with the rabies virus. Both
showed increased survival time as compared with the virus controls. These fi ndings suggest that the rhuIFN α-2a might
have some anti-viral activity, which can be used for the treatment of rabies infection. Further research on the effi cacy
of interferon along with anti-viral drugs for the treatment will be helpful in designing combination therapy against the
disease.
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Keywords
LD50, mice, rabies, recombinant human interferon-α-2a
Citation
Roy S, Patil D, Ghadigaonkar S, Roy R, Mukherjee S, Chowdhary A, Deshmukh R. A preliminary study of recombinant human interferon-α-2a activity against rabies virus in murine model. Indian Journal of Medical Microbiology. 2015 Jan-Mar ; 33 (1): 132-135.