Polymicrobial chronic endophthalmitis diagnosed by culture and molecular technique.
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Date
2014-07
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Abstract
Accurate etiological diagnosis is the key to prevention of ocular morbidity in endophthalmitis cases. A 66 year old male
was suffering from chronic endophthalmitis post-cataract surgery. Polymerase chain reaction examination on anterior
chamber fluid was positive for Propionibacterium acnes but negative for the panfungal genome. He was advised
vitrectomy with intravitreal injections. Polymerase chain reaction of vitreous aspirate was positive for P.acnes as well
as panfungal genome. The vitreous sample also grew yeast in culture which was identified as Candida pseudotropicalis.
Patient was treated on an alternate day regimen of intravitreal Vancomycin and Amphotericin B in the post-operative
period. There was improvement in vision at final follow up. Chronic endophthalmitis can have polymicrobial etiology
which will require appropriate diagnostic and therapeutic strategies. The role of molecular testing is vital in these cases
as growth in culture is often negative.
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Keywords
Endophthalmitis, polymerase chain reaction, propionibacerium acnes
Citation
Mukherjee A, Pramanik S, Das D, Roy R, Therese KL. Polymicrobial chronic endophthalmitis diagnosed by culture and molecular technique. Indian Journal of Medical Microbiology. 2014 Jul-Sept ; 32 (3): 331-332.