Clinical and microbiological characteristics of Rhodotorula mucilaginosa infections in a tertiary-Care facility.
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Date
2014-07
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Abstract
Background: Rhodotorula spp. are an emergent opportunistic pathogen, particularly in immunocompromised
individuals. Materials and Methods: The aim of the study was to review reported cases of Rhodotorula infection
over a period of 9 years to determine epidemiology, risk factors, treatment and outcome. Results: The Rhodotorula
spp. were isolated from cerebrospinal fluid (9) and blood (5). The most common pre-disposing factors were prolonged
hospital stay (>1 month) and prolonged usage of broad-spectrum antibiotics (>1 month). All the isolates were identified
as R. mucilaginosa by conventional methods. Amphotericin B demonstrated lowest minimum inhibitory concentration
(MIC) as compared with other anti-fungal agents (fluconazole, itraconazole and voriconazole). Conclusions: The
recognition of unusual yeasts as an agent of life-threatening infection and their intrinsic resistance increases the burden
on the mycology laboratory for complete species identification and to determine minimum inhibitory concentration.
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Keywords
Anti‑fungal susceptibility, emergent yeast, immunosuppression, Rhodotorula spp.
Citation
Capoor M R, Aggarwal S, Raghvan C, Gupta D K, Jain A K, Chaudhary R. Clinical and microbiological characteristics of Rhodotorula mucilaginosa infections in a tertiary-Care facility. Indian Journal of Medical Microbiology. 2014 Jul-Sept ; 32 (3): 304-309.