Histopathological Spectrum of Renal Lesions in Adults with Proteinuria.
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Date
2014-09
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Abstract
Background and Objectives: Proteinuria of more than 2.0 g in 24 hours is indicative of renal disease
and a value of more than 3.5 g is a component of Nephrotic syndrome. The pathology resulting in proteinuria
can be glomerular, tubular and others. Renal biopsy is gold standard in evaluation and management of
patients with proteinuria especially Nephrotic syndrome. Methods: A retrospective analysis of all renal
biopsies from adult patients with significant proteinuria over a period of 4 years was performed to study the
pattern of renal pathology. The morphological findings were correlated with Clinical findings, laboratory
findings &Immunofluorescence profile as per availability. Results: It was observed that clinical diagnosis
matched the final pathological diagnosis in 79 (58.09%) cases. Further, Light Microscopy findings corresponded
with Immunofluorescence in 142 out of 158 cases, while the diagnosis was changed in 16 (10.13%) cases after
IF. Conclusions: The results thus indicate that renal biopsy along with IF plays an important role in diagnosis of
cases with significant proteinuria a fact highlighted by low concordance % between the clinical and the
pathological diagnosis. An accurate diagnosis is not only essential to initiate appropriate therapy but also in
prognostication of renal lesions.
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Keywords
Renal Biopsy, Proteinuria, Immunoflourescence
Citation
Selhi Pavneet Kaur, Sharma Nisha, Kaur Harpreet, Malhotra Vineeta. Histopathological Spectrum of Renal Lesions in Adults with Proteinuria. National Journal of Integrated Research in Medicine. 2014 Sept-Oct ; 5 (5): 90-95.