Evaluation of Haemoglobin and Iron Levels in Serum of Patients with Oral Sub Mucous Fibrosis: A Clinical Study.
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Date
2014-09
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Abstract
Background: Oral sub mucous fibrosis (OSMF) is a chronic, insidious oral mucosal condition
affecting the most parts of the oral cavity with high malignant transformation rate triggered by areca nut
chewing, nutritional deficiencies, immunologic processes, and genetic predisposition. OSMF causes significant
haematological abnormalities resulting in change in levels of various elements. Aim and Objectives: The aim of
this study was to estimate the haemoglobin and iron levels in serum among patients with oral sub mucous
fibrosis and to compare the values with healthy subjects. Materials and Methods: In this clinical study 50
patients who were diagnosed histopathologically with OSMF and 50 healthy individuals will be included, and
the values of haemoglobin levels will be estimated using Sahli's serum iron by Ferrene methods. Results: OSMF
patients showed significantly lower levels of haemoglobin and serum iron when compared with the healthy
subjects. Conclusion: The present study shows the serum iron assessment for patients with oral sub mucous
fibrosis. Determining iron status is a part of biochemical assessment, which may be of proactive intervention
for high-risk groups. It is suggested that the biochemical assessment of oral precancerous conditions may help
in early diagnosis and prognosis. It is also of key importance that iron therapy should be instituted parallel with
the initial diagnosis along with a proper balanced diet, as a part of the overall treatment of oral sub mucous
fibrosis with other modes of treatment. This helps to stop the further progression of the condition.
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Keywords
Haemoglobin, Iron Levels, Oral Sub Mucous Fibrosis
Citation
Pathak Deep, Jani Mehul D, Machhi Mansi. Evaluation of Haemoglobin and Iron Levels in Serum of Patients with Oral Sub Mucous Fibrosis: A Clinical Study. National Journal of Integrated Research in Medicine. 2014 Sept-Oct ; 5 (5): 30-34.