Parental Obesity and Serum Leptin Levels among North Indian Obese Adults.
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Date
2014-09
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Abstract
Background And Objectives: Obesity is increasing worldwide as an epidemic. Recent advances in
biology of adipose tissue have revealed that adipose tissue in addition to its role as an energy reservoir,
modulates energy metabolism via secretion of circulating adipocytokines. Leptin is one such adipocytokine
which is essential for body weight homeostasis. There exists complex interaction of genetic and environmental
factors in obesity. Various studies have shown genetic influence of parental fatness in childhood obesity but
the effect of parental obesity in adult obesity as well as leptin level is not clear, therefore present study was
aimed to determine whether parental obesity might contribute to adult obesity as well as serum leptin levels
in obese adults. Material and Methods: Study consisted of forty five obese adults with Body Mass Index≥27
and control group included forty five lean adults with Body Mass Index≤22. Information regarding parental
obesity was obtained from each participant in a prestructured questionnaire. Blood samples were collected
from both groups and serum leptin levels were measured by Radioimmunoassay. Results: About 62 percent of
case group was found to have parental history of obesity. In contrast 29 percent subjects in control group had
obese parents. Moreover, the mean of serum leptin levels in obese adults with history of obese parents was
significantly higher than obese adults without the history of obese parents (males:19.26±2.69 vs
15.75±2.19,p=0.04 and females: 37.0±7.55 vs26.86±3.72,p =0.02). Conclusion: Parental obesity plays an
important role in obesity and serum leptin level during adulthood.
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Keywords
Body Mass Index, Leptin, Parental obesity
Citation
Khatri Anshu, Changotra Parshant, Aggarwal Tanu, Sayedda Kauser. Parental Obesity and Serum Leptin Levels among North Indian Obese Adults. National Journal of Integrated Research in Medicine. 2014 Sept-Oct ; 5 (5): 1-4.