Deoxyribonucleic acid repair gene X-ray repair cross-complementing group 1 polymorphisms and non-carcinogenic disease risk in different populations: A meta-analysis.
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Date
2013-10
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Abstract
PURPOSE: This study aims to assess a meta‑analysis
of the association of X‑ray repair cross‑complementing
group 1 (XRCC1) polymorphisms with the risk of various
non‑carcinogenic diseases in different population.
MATERIALS AND METHODS: This meta‑analysis was
performed by critically reviewing reveals 38 studies involving
10043 cases and 11037 controls. Among all the eligible
studies, 14 focused on Arg194Trp polymorphism, 33 described
the Arg399Gln and three articles investigated on Arg280His.
Populations were divided into three different ethnic subgroups
include Caucasians, Asians and other (Turkish and Iranian).
RESULTS: Pooled results showed no correlation
between Arg194Trp and non‑carcinogenic disease.
There was only weak relation in the recessive (odds
ratio [OR] =1.11, 95% confidence interval [CI]: 0.86‑1.44)
model in Asian population and dominant (OR = 1.04,
95% CI: 0.66‑1.63) model of other populations. In
Arg399Gln polymorphism, there was no relation with
diseases of interest generally. In the pooled analysis,
there were weak relation in the dominant (OR = 1.08,
95% CI: 0.86‑1.35) model of Asian population and quite
well‑correlation with recessive (OR = 1.49, 95% CI:
1.19‑1.88), dominant (OR = 1.23, 95% CI: 0.94‑1.62), and
additive (OR = 1.23, 95% CI: 0.94‑1.62) models of other subgroup. For Arg280His, there was a weak relation only
in the dominant model (OR = 1.06, 95% CI: 0.74‑1.51).
CONCLUSION: The present meta‑analysis correspondingly
shows that Arg399Gln variant to be associated with
increased non‑carcinogenic diseases risk through
dominant and recessive modes among Iranian and Turkish
population. It also suggests a trend of dominant and
recessive effect of Arg280His variant in all population and
its possible protective effect on non‑carcinogenic diseases.
Description
Keywords
Arg194Trp, Arg280His, Arg399Gln, ethnicity, non‑carcinogenic diseases, polymorphisms, X‑ray repair cross‑complementing group 1 gene
Citation
Larijani Bagher, Asl Javad Mohammadi, Keshtkar Abbas, Saki Najmaldin, Larijani Fatemeh Ardeshir, Rahim Fakher. Deoxyribonucleic acid repair gene X-ray repair cross-complementing group 1 polymorphisms and non-carcinogenic disease risk in different populations: A meta-analysis. Indian Journal of Human Genetics. 2013 Oct-Dec ;19 (4): 494-511.