Analysis of association of TaqI VDR gene polymorphism with the chronic periodontitis in Dravidian ethnicity.
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Date
2013-10
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Abstract
AIM: The aim of this study is to analyze the association of
TaqI vitamin D receptor (VDR) gene polymorphism with the
chronic periodontitis (CP) in Dravidian ethnicity.
MATERIALS AND METHODS: A total of 120 subjects were
recruited for this study, which included 60 CP and 60 healthy
controls. TaqI VDR gene polymorphism was analyzed
using specific primers and amplified by polymerase chain
reaction (PCR) and visualized under 2% agarose gel.
RESULTS: Our study results showed that Tt and tt genotype
had a higher frequency of occurrence in CP compared with
controls. Similarly, t allele was found to be associated with CP.
CONCLUSION: Our study concludes that TaqI VDR gene
polymorphism is associated with CP in Dravidian ethnicity.
Description
Keywords
Alleles, chronic periodontitis, polymorphism, TaqI, vitamin D receptor
Citation
Kaarthikeyan Gurumoorthy, Jayakumar N D, Padmalatha O, Varghese Sheeja, Anand B. Analysis of association of TaqI VDR gene polymorphism with the chronic periodontitis in Dravidian ethnicity. Indian Journal of Human Genetics. 2013 Oct-Dec ;19 (4): 465-468.