Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!.
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Date
2013-10
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Abstract
INTRODUCTION: Non‑syndromic tooth agenesis is a
congenital anomaly with significant medical, psychological,
and social ramifications. There is sufficient evidence to
hypothesize that locus for this condition can be identified
by candidate genes.
AIM OF THE STUDY: The aim of this study was to test
whether MSX1 671 T > C gene variant was involved
in etiology of non‑syndromic tooth agenesis in Raichur
patients.
MATERIALS AND METHODS: Blood samples were
collected with informed consent from 50 subjects having
non‑syndromic tooth agenesis and 50 controls. Genomic
deoxyribonucleic acid (DNA) was extracted from the blood
samples, polymerase chain reaction (PCR) was performed,
and restriction fragment length polymorphism (RFLP) was
performed for digestion products that were evaluated.
RESULTS: The results showed positive correlation between
MSX1671 T > C gene variant and non‑syndromic tooth
agenesis in Raichur patients.
CONCLUSION: MSX1 671 T > C gene variant may be a
good screening marker for non‑syndromic tooth agenesis
in Raichur patients.
Description
Keywords
MSX1 mutation, non‑syndromic, tooth agenesis
Citation
Reddy Naveen Admala, Adusumilli Gopinath, Devanna Raghu, Mayur Rohra G, Pichai Saravanan, Arujnan Sharmila. Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!. Indian Journal of Human Genetics. 2013 Oct-Dec ;19 (4): 459-464.