Distribution and genotype frequency of the C1431T and pro12ala polymorphisms of the peroxisome proliferator activator receptor gamma gene in an Iranian population.
Loading...
Date
2013-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
BACKGROUND: Peroxisome proliferator activator receptor
gamma (PPARγ) is a nuclear transcription factor regulating
multiple genes involved in cell growth, differentiation,
carbohydrate and lipid metabolism and energy production.
Several genetic variations in the PPARγ gene have
been identified to be associated with diabetes, obesity,
dyslipidemia, insulin resistance, metabolic syndrome and
coronary artery disease. The present study was designed
to explore the distribution of two common single nucleotide
polymorphisms of the PPARγ gene (C1431T and Pro12Ala)
in an Iranian population.
MATERIALS AND METHODS: Genotype frequencies for
these two polymorphisms were compared for 160 healthy
Iranian individuals with reports from other populations. The
Genotyping was performed using real‑time polymerase
chain reaction.
RESULTS: The genotype distribution of the C1431T PPARγ
polymorphism was 0.869 for the CC genotype, 0.119 for
the CT genotype and 0.013 for uncommon TT genotype.
Allelic frequencies were 0.93 for C and 0.07 for T allele
respectively. For the Pro12Ala polymorphism of PPARγ
gene, genotypic distributions and allelic frequencies were,
0.813 for CC, 0.181 for CG and 0.06 for GG and 0.903
for C and 0.097 for G respectively. Allelic and genotypic
frequencies for both polymorphisms of PPARγ gene were
in Hardy‑Weinberg equilibrium.
CONCLUSIONS: Iran is a country with an ethnically
diverse population and a comparison of allelic and genotypic frequencies of PPARγ C1431T and Pro12Ala
polymorphisms between our population and others showed
significant differences.
Description
Keywords
Iranian population, PPARγ gene, single nucleotide polymorphism
Citation
Rooki Hassan, Haerian Monir Sadat, Azimzadeh Pedram, Ebrahimi Mahmoud, Mirhafez Reza, Ferns Gordon, Ghayour Mobarhan-Majid, Zali Mohammad Reza. Distribution and genotype frequency of the C1431T and pro12ala polymorphisms of the peroxisome proliferator activator receptor gamma gene in an Iranian population. Indian Journal of Human Genetics. 2013 Oct-Dec ;19 (4): 423-429.